Differential Sulfations and Epimerization Define Heparan Sulfate Specificity in Nervous System Development
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منابع مشابه
Differential Sulfations and Epimerization Define Heparan Sulfate Specificity in Nervous System Development
Heparan sulfate proteoglycans (HSPG) are components of the extracellular matrix through which axons navigate to reach their targets. The heparan sulfate (HS) side chains of HSPGs show complex and differentially regulated patterns of secondary modifications, including sulfations of distinct hydroxyl groups and epimerization of an asymmetric carbon atom. These modifications endow the HSPG-contain...
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ژورنال
عنوان ژورنال: Neuron
سال: 2004
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(04)00084-4